WEDNESDAY, August 24, 2022 (HealthDay News) — According to research published in the July issue of Human reproduction.
Emil Andersen, from the University of Copenhagen in Denmark, and his colleagues looked at the acute and long-term effects of weight loss on sperm parameters. The analysis included 56 obese men assigned to an initial eight-week low-calorie diet (800 kcal/day), followed by randomization at 52 weeks to placebo and usual activity (placebo), exercise training, and placebo (exercise), Glucagon As liraglutide analog peptide 1 (GLP-1) and usual activity (liraglutide), or liraglutide in combination with physical training (combination).
The researchers found that the men lost an average of 16.5 kg of body weight on the low-calorie diet, which increased sperm concentration by 1.49 times and sperm count by 1.41 times. For the men who maintained the weight loss, these improvements were maintained for 52 weeks, but the improvements were not maintained for the men who regained the weight. No changes were observed in semen volume, sperm motility or number of motile sperm.
“Persistent improvement in sperm concentration and count after sustained weight loss with exercise and/or a GLP-1 receptor agonist may therefore also result in improved male fertility,” the authors write.
The study was supported by a grant from the Novo Nordisk Foundation, and several authors disclosed financial ties to Novo Nordisk.
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